Tooth discoloration brown, yellow, or gray staining has been reported. Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases. Coadministration of probenecid is not recommended. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation.
It is not known whether this potentiation of amoxicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted. The amoxicillin doses in rats and mice based on body surface area were approximately 4 and 2 times the maximum recommended adult human oral dose mg every 12 hours.
For clavulanate, these dose multiples were approximately 9 and 4 times the maximum recommended adult human oral dose mg every 8 hours. There are, however, no adequate and well-controlled studies in pregnant women. Contiene due diversi medicinali chiamati amoxicillina e acido clavulanico. L'altro componente attivo acido clavulanico impedisce che questo avvenga. Non prenda Augmentin se uno di questi casi la riguarda. Se ha dubbi, parli con il medico o il farmacista prima di prendere Augmentin.
Faccia particolare attenzione con Augmentin Parli con il medico o il farmacista prima di prendere questo medicinale se lei: Questi possono includere reazioni allergiche, convulsioni e infiammazioni dell'intestino. Lei deve prestare attenzione ad alcuni sintomi durante l'assunzione di Augmentin, al fine di ridurre qualsiasi rischio. Vedere "Condizioni a cui lei deve prestare attenzione" al Paragrafo 4.
Assunzione con altri medicinali Informi il medico o il farmacista se lei sta usando o ha di recente usato qualsiasi altro medicinale, compresi quelli acquistabili senza prescrizione medica e prodotti erboristici. Hepatic events have been reported predominantly in males and elderly patients and may be associated with prolonged treatment. These events have been very rarely reported in children. In all populations, signs and symptoms usually occur during or shortly after treatment but in some cases may not become apparent until several weeks after treatment has ceased.
These are usually reversible. Hepatic events may be severe and, in extremely rare circumstances deaths have been reported. These have almost always occurred in patients with serious underlying disease or taking concomitant medications known to have the potential for hepatic effects see section 4. Antibiotic-associated colitis has been reported with nearly all antibacterial agents including amoxicillin and may range in severity from mild to life threatening see section 4.
Therefore, it is important to consider this diagnosis in patients who present with diarrhoea during or subsequent to the administration of any antibiotics. Anti-peristaltic medicinal products are contraindicated in this situation. Periodic assessment of organ system functions, including renal, hepatic and haematopoietic function is advisable during prolonged therapy.
Appropriate monitoring should be undertaken when anticoagulants are prescribed concomitantly. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation see sections 4. In patients with renal impairment, the dose should be adjusted according to the degree of impairment see section 4. In patients with reduced urine output, crystalluria has been observed very rarely, predominantly with parenteral therapy.
During the administration of high doses of amoxicillin, it is advisable to maintain adequate fluid intake and urinary output in order to reduce the possibility of amoxicillin crystalluria. In patients with bladder catheters, a regular check of patency should be maintained see section 4. During treatment with amoxicillin, enzymatic glucose oxidase methods should be used whenever testing for the presence of glucose in urine because false positive results may occur with non-enzymatic methods.
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